Sr. Staff Scientist

Company: The University Of Chicago
Location: Chicago
Posted on: March 30, 2025

Job Description:

DepartmentBSD BMB - Perozo LabAbout the DepartmentThe Center for Mechanical Excitability (CME) is dedicated to the study of the mechanobiome, the biological construct where forces are sensed, transduced, and exerted as part of a broad range of processes, both physiological and pathophysiological. Our approach covers a range of biological mechanisms both at the mesoscale and the nanoscale. We use an advanced toolkit that includes biochemistry, biophysics, cell and molecular biology, structural biology and imaging, as well as AI-driven computational modeling and bioinformatics; all within the context of evolutionary biology.The Department of Biochemistry and Molecular Biology (BMB) studies how biomolecules function and interact to drive the complex, diverse, and adaptive behaviors of living systems. Our focus is on biological mechanisms described at the molecular level. We are highly collaborative and often employ multiple approaches to address otherwise intractable questions. We have particular strengths in membrane proteins and RNA biochemistry and are pioneers in all areas of biophysics, structural biology, biochemistry, and protein engineering and design.Job SummaryThe Sr. Staff Scientist will lead a research program focused on genetic modifications in model epithelial enterocytes and develop full mouse lines associated with two identified TMC channels (TMC4 and TMC5). Thede will be analyzed by electrophysiological methods and characterized biochemically with the express goal of developing a pipeline to obtain their structure.Responsibilities

• Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information.
• Develops laboratory protocols and training on new techniques. Manage, analyze and make recommendations on complex data sets for research.
• Creates first drafts for scientific writing and publications, including protocols and grants.
• Trains and mentors laboratory personnel.
• Performs other related work as needed.Minimum QualificationsEducation: Minimum requirements include a PhD in related field.Work Experience: Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline.Certifications: ---Preferred QualificationsExperience:
  • Experience in the genetic manipulation of invertebrate (cnidarian) model systems, and a general understanding of membrane protein biochemistry.
  • Experience with the following:
    • Gene knock-downs by RNAi methods.
    • Development of knock-in line using CRISPR/Cas9 methods.
    • In-situ hybridization.
    • Single channel and whole cell patch clamp.
    • Fluorescence imaging.
    • Cell fractionation.
    • Membrane Protein purification.
    • Single particle CryoEM.Working Conditions
      • Lab Environment.
      • Weekend/Evening Hours: As needed.Application Documents
        • Resume (required)
        • Cover Letter (preferred)When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.Job FamilyResearchRole ImpactIndividual ContributorScheduled Weekly Hours40Drug Test RequiredNoHealth Screen RequiredNoMotor Vehicle Record Inquiry RequiredNoPay Rate TypeSalaryFLSA StatusExemptPay Range$80,000.00 - $100,000.00The included pay rate or range represents the University's good faith estimate of the possible compensation offer for this role at the time of posting.Benefits EligibleYesThe University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.Posting StatementThe University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu. Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.The University of Chicago is an urban research university that has driven new ways of thinking since 1890. Our commitment to free and open inquiry draws inspired scholars to our global campuses, where ideas are born that challenge and change the world.We empower individuals to challenge conventional thinking in pursuit of original ideas. Students in the College develop critical, analytic, and writing skills in our rigorous, interdisciplinary core curriculum. Through graduate programs, students test their ideas with UChicago scholars, and become the next generation of leaders in academia, industry, nonprofits, and government.
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Keywords: The University Of Chicago, Chicago , Sr. Staff Scientist, Other , Chicago, Illinois