Senior Associate Scientist, in vivo Biology

Company: Ensoma
Location: Chicago
Posted on: April 23, 2025

Job Description:

Location: Boston, MAJob Id: R095-R# of Openings: 1Senior Associate Scientist, in vivo BiologyWe are seeking an independent and highly motivated Senior Associate Scientist to join our research and development team to conduct complex studies using animal models and ex vivo sample analysis to support the development of novel therapeutics. You will utilize your strong in vivo technical skills and solid understanding of disease animal models in the hematology/immunology field to help execute a wide variety of projects across Ensoma's portfolio.You will join a team of scientists dedicated to moving a novel gene therapy drug candidate into the clinic. Join us and be part of building a company revolutionizing the reach and access of the curative power of genomic medicines for patients with serious diseases.Responsibilities:

• Conduct complex in vivo experiments using disease and immunocompromised mouse models
• Perform primary cell isolation and culture
• Execute in vitro and ex vivo cell-based assays
• Manage internal and external mouse colonies
• Analyze data and present results at group meetings and conferences
• Contribute to publications and written reports for regulatory filings
• Maintain laboratory equipment and rooms as requiredQualifications:Required:
  • A Bachelor's Degree in a biological science with a minimum of six years or a Master's Degree with a minimum of three years of academic and/or industry experience
  • Experience in rodent handling dosing such as intravenous (IV), intraperitoneal (IP), intramuscular (IM), or subcutaneous (SC) and tissue collection, preferably in hemato-lymphoid organs (bone marrow, spleen, blood)
  • Demonstrated experience in performing primary cell cultures, hematopoietic stem cell and/or immune cell-based in vitro and in vivo assays
  • Ability to design experiments and troubleshoot technical hurdles independentlyPreferred:
    • Experience with multi-color flow cytometry and ability to operate flow cytometers independently
    • Experience with complex in vivo protocols including bone marrow transplant
    • Demonstrated experience in erythroid cell biology
    • Experience in gene therapyAbout Ensoma:Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask: What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?Ensoma was founded to answer these questions through our Engenious platform that can transform the hematopoietic (blood & immune) system with a single treatment. Our Engenious gene therapy platform is the first to precisely engineer any or all hematopoietic and immune cells with a one-time, off-the-shelf in vivo treatment. Engenious therapies have an unmatched capacity to deliver all modern genetic modification tools and set a new standard for versatile cell programming and control across a range of complex diseases. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell and gene therapy field, we feel an urgency and passion for our work driven by its potential global impact.A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving, and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.Ensoma is supported by top-tier investors, a strategic collaboration with Takeda, and a passionate team committed to a bold global vision for gene therapy. Ensoma is based in Boston, Massachusetts. For more information, please visit www.ensoma.com.
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Keywords: Ensoma, Chicago , Senior Associate Scientist, in vivo Biology, Other , Chicago, Illinois