Senior Scientist, HSC Gene Editing

Company: Ensoma
Location: Chicago
Posted on: April 5, 2025

Job Description:

We believe the future of medicine lies within us.Fearless, inspired, connected---and awesomeThese are some of the words we use to describe ourselves and our culture. We are committed to a better future for patients, each other, and the community. We believe our role in making that a reality is as medical innovators, and the key to our success will be the power of our platform.At Ensoma, we pride ourselves on being a team of entrepreneurs with trailblazer mindsets, fearlessly pushing the boundaries of science.Open PositionLocation: Boston, MAJob Id: tbd# of Openings: 1Scientist/Senior Scientist, Gene EditingWe are seeking a highly motivated and skilled Scientist/Senior Scientist to join our Gene Editing team in Boston as we develop innovative, precise gene-editing therapeutics for treating diseases with unmet medical needs. This position is ideal for a candidate with a passion for cutting-edge science and a desire to make a significant impact on the therapeutic gene editing field. As part of a growing team, you will have the opportunity to work alongside experienced researchers and develop your skills in cell biology, molecular biology, and biochemistry. You will also collaborate with colleagues from the genomics, bioinformatics and in vivo teams. This is an exciting opportunity for someone who has a strong scientific, educational background and hands-on experience to continue to build upon this foundation in a role with high impact potential.Responsibilities:

• Develop and optimize methods for efficient gene editing in cell lines and primary cells.
• Deep understanding of gene editing experimental results.
• Ensuring high-quality data generation.
• Interpret experimental data, integrate findings with current scientific literature, and propose innovative solutions.
• Present findings to internal teams, multidisciplinary research groups, and at external meetings or conferences when appropriate.
• Provide guidance and mentorship to junior scientists and research associates, fostering a collaborative research environment.
• Identify and escalate technical challenges, incorporating feedback to optimize research outcomes.Qualifications:Required:
  • Deep understanding of gene editing using CRISPR systems
  • A PhD in molecular biology, cell biology, biochemistry, biotechnology, or a related field with 2+ years of industry experience
  • Experience working with hematopoietic stem cells
  • Experience with working with RNA
  • Experience with culturing cell lines and primary cells
  • Experience with cellular and molecular biology techniques
  • Proven ability to advance multiple projects and manage resourcesPreferred:
    • Experience with viral gene delivery
    • HTP screening methodsAbout Ensoma:Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask: What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?Ensoma was founded to answer these questions. Our platform is the most advanced in vivo hematopoietic stem cell (HSC) engineering technology. It combines an off-the-shelf, in vivo delivery system with an advanced gene engineering toolkit. Through its HSC engineering platform, Ensoma can selectively and durably modify any cells of the entire hematopoietic system to treat diseases with unprecedented versatility - all with a one-time therapy. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell, gene therapy and gene editing field, we feel an urgency and passion for our work driven by its potential global impact.A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts. For more information, please visit www.ensoma.com.
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